Ingredient: Trazodone Hydrochloride Manufacturer: Sun Pharma Brand Name: Trazodone Category: Antidepressants Trazolan 50 mg (100 pills) Item price: $0.23 Characteristics of the substance Trazodone Thiazolopyridine derivative; the chemical structure does not apply to tricyclic, tetracyclic or other groups of antidepressants. Trazodone hydrochloride is an odorless white crystalline powder, readily soluble in water. The molecular weight is 408.33. Pharmacology Pharmacological action - antidepressant. The mechanism of action is not fully understood. Preclinical studies have shown that trazodone selectively inhibits serotonin reuptake by brain synaptosomes and acts as an antagonist of 5-HT2A / 2C serotonin receptors. It does not inhibit MAO, does not stimulate the central nervous system. It is an antagonist of alpha1-adrenergic receptors. usatrusted.over-blog.com/2020/05/buy-testosterone-p100-100mg-10ml-1-vial-biomex-labs.html It stops the mental (affective tension, fear, insomnia) and somatic (palpitations, headache, myalgia, rapid urination, increased sweating) manifestations of anxiety. It increases the depth and duration of sleep in patients with depression, restores the physiological structure of sleep. It is well absorbed from the digestive tract. Reception of trazodone during or immediately after a meal slows down the rate of absorption, reduces Cmax of trazodone in the blood and increases Tmax (Tmax is 0.5–2 hours). Plasma protein binding 89–95%. It passes through the histohematological barriers, including the BBB. It is metabolized in the liver, mainly with the participation of the isoenzyme CYP3A4 of cytochrome P450, the active metabolite is m-chlorophenylpiperazine. T1 / 2 is two-phase: the duration of the early phase is 3–6 hours, of the late 5–9 hours; cumulation is possible in some patients. It is excreted in the bile (20%) and urine (75%, including 70% in the form of inactive metabolites) within 98 hours after administration. There is evidence of the effectiveness of trazodone in bulimia, kleptomania, pain syndrome in diabetic neuropathy and other types of chronic pain, phobias, including agoraphobia, panic attacks, acute withdrawal syndrome with alcoholism and for the prevention of migraine. Use of the substance Trazodone Depressive states of various etiologies (endogenous, psychotic, neurotic, somatogenic, etc.) with severe anxiety, tension.
Contraindications Hypersensitivity, alcohol intoxication and intoxication with sleeping pills, age up to 6 years. Application restrictions
Myocardial infarction (early recovery period), AV block, arterial hypertension (dose adjustment of antihypertensive drugs may be required), ventricular arrhythmia, a history of priapism, liver and / or renal failure, under 18 years of age. oneanabolics.blogspot.com/2020/05/toremfine-20-mg-100-tabs-toremifene.html Pregnancy and lactation Should not be used by pregnant women. In animal experiments, it was shown that trazodone at doses 30–50 times higher than the MPDF causes congenital malformations and increases the frequency of fetal resorption. The FDA category of action for the fetus is C. At the time of treatment should stop breastfeeding. Trazodone and its metabolites are found in the milk of lactating rats. It is not known whether trazodone is secreted into human milk.
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