Ingredient: Letrozole Manufacturer: Novartis Brand Name: Femara Price Femara: $4.63 Composition The active ingredient is letrozole in a dosage of 2.5 mg. Other substances are auxiliary. Release form The drug is available in tablet form. In appearance, they are yellow biconvex round coated tablets. The letters “FV” are engraved on one side, and “CG” on the other. Packed in plastic blisters of 10 pcs. In a cardboard box are 30 tablets. Pharmachologic effect Pharmacological action - antitumor, antiestrogen. The active ingredient blocks the aromatase enzyme. Due to this, the production of estrogen in the tumor and peripheral tissues is reduced. Adjuvant therapy reduces the risk of a worsening of the patient's condition by 42%. Increases the level of survival, prevents the development of a tumor in the second breast. During treatment with letrozole, the risk of death in women with involved lymph nodes decreases by 40%. Pharmacodynamics of the drug Letrozole suppresses a stimulating estrogenic effect. This creates the prerequisites for suppressing tumor growth. In this case, the production of other steroid hormones in the adrenal glands, in the thyroid gland is not disturbed, androgens do not accumulate in the tissues. Suppression of female sex hormones is observed during the entire course of therapy. Additional administration of glucocorticoids is not required. oneanabolic.sport.blog/2020/01/23/equipose-200-boldenone-undecylenate-200mg-10ml/ Letrozole is rapidly absorbed in the stomach. The average concentration in the tissues is observed after 1-2 hours. It depends on the presence of a food lump in the stomach. But a change in suction rate is not critical. It is excreted within 2 days through the urinary system. Slightly with feces. With prolonged use, signs of accumulation in the tissues were not detected. Indications for use The drug is used to treat oncopathologies in the active stage, as part of adjuvant therapy only for postmenopausal women (natural or stimulated). Indications for appointment:
Contraindications The medicine is strictly prohibited for women in the reproductive period, young girls. Other contraindications:
Side effects Side effects are associated with the antiestrogenic effect of the drug. Frequent complaints of patients:
Other unpleasant symptoms develop extremely rarely. With the development of side effects, further treatment tactics should be discussed with your doctor. Compatibility with other drugs Clinical experience with the use of letrozole in combination with other antitumor agents is currently not available. Simultaneous administration with valfarin and cimetidine preparations is allowed.
The simultaneous administration of letrozole with tamoxifen, other estrogen antagonists, or estrogens is prohibited. At a dose 100 times higher than recommended, it can inhibit the metabolism of diazepam. The diagnosis of breast cancer and alcohol are incompatible concepts. Therefore, the use of letrozole is strictly prohibited. Dosage regimen - instructions for the patient
Femara is an oral drug. The recommended dosage is 1 tablet per day. The duration of therapy is no more than 5 years. If signs of tumor growth are detected, then the drug is canceled. For patients with kidney pathologies, dose adjustment is not performed. With a severe form of urinary system dysfunction, a woman should be under dynamic observation. Overdose In the medical literature, several cases of overdose of letrozole are described. A specific antidote has not been developed. The treatment is symptomatic. In severe cases, dialysis is indicated. Terms of sale Femara is a prescription drug. You can buy it only in pharmacies. The price in Moscow is in the range of 4000-6000 rubles for packaging No. 30. With the wholesale method of purchase, the drug will be cheaper. In addition, there are cheaper full analogues of the drug.
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